Nevada Governor an Online Gaming Pioneer | BingoLingo.com

Nevada Governor Brian Sandoval said that Nevada took a big step forward last week when the state?s gambling commission awarded the first two online gaming licenses. Sandoval has been a pioneer in getting Nevada ready for online gambling. Last Thursday the Nevada Gaming Commission awarded online gambling licenses to Bally Technologies and Interna?tional Game Technology. (IGT) In an interview last Friday Sandoval said that since 2002 he and then Gaming Control Board Chairman Dennis Nylander worked on legislation that ?essentially provided a foundation for Nevada to get into Internet gaming.? At the time Sandoval was chairman of the Nevada Gaming Com?mission.

In 2011 as Governor Sandoval proposed legislation that directed Gaming Control to set up regulations for licensing internet gaming in the state. The legislation was completed and resulted in the issuance of the first two online gaming licenses. Sandoval said ?I can?t take all the credit? and added Assembly Judiciary Chairman William Horne guided the bill through committee and the lower house. Sandoval said that the licensing regulations combined with legislation that allows technological examination and certification of new gaming technologies are designed to keep Nevada the ?gold standard? of legal gambling. Sandoval said that the legislation allowing the examination of new gaming technologies was needed because the Gaming Control?s small technology staff was having trouble keeping up with the changes in gaming technology.

The backlog at Gaming Control was allowing new technologies to reach casinos in jurisdictions other than Nevada. Sandoval stated ?I?m determined that Nevada maintain its position as leader of gaming in the world.? Sandoval was asked by reporters about internet hacking and security concerns for internet gambling. Sandoval said the issue has been a top priority for the Gaming Policy Committee and Gaming Control. The Governor said the security programs are so good they can catch players cheating at an online poker table. Sandoval stated ?It will not allow minors access, and will ensure that bets are only taken in certain places.? The governor said that one long term goal is to have online gambling companies set up their servers, research and development departments in Nevada.

What does all this mean to online bingo players? If Nevada is successful other states are sure to follow and allow online gaming including online bingo. Nevada?s regulations could serve as a template for other states that want to implement intrastate online gaming. In addition to generating extra revenues in Nevada the development of the online gaming industry will create many good paying jobs.

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Fifty Shades of Grey Sparks Rise in S&M, Bondage, Rope Sales

Fifty Shades of Grey is a must-read for women everywhere. Apparently, the EL James novel is also making S&M and bondage gear a must-buy for some.

The buzzed-about book has left unassuming New York women so feverish, they’ve been snapping up the tools and toys that the hunky Christian Grey favors.

They’re even slipping into stores and asking for bondage material - the type of natural filament rope used in the trilogy - the New York Post reports.

“Oh, we’ve been selling rope to women,” says Clifton Kahn, owner of Lexington Hardware on the Upper East Side. “I’d say tenfold more rope than usual."

"The women are definitely buying, and it’s still continuing.”

Apparently tying someone up isn't expensive. The store’s most popular item is soft-cotton “clothes line” rope, which retails at a bargain $5 for 50 feet.

Tarzian Hardware in Park Slope, Brooklyn, has also seen the trend.

“It’s usually men buying rope, but women, they’ve been coming in the last few months,” the manager told the newspaper. “I’ve actually read the book. So when the women began buying rope, it was kind of like, ‘Hmmm, that does seem unusual.’”

While New Yorkers act out their S&M fantasies, casting the movie roles of Christian and Anastasia has become an online fantasy game of sorts this spring.

Some stars, such as Ian Somerhalder, have expressed interest in the film themselves. Who can you see as the two leads? Vote in our polls below!

Who should play Christian?

Who should play Ana?

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Ghana economy grows 8.7 pct in first quarter

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Happy accident answers cell signal controversy

ScienceDaily (June 27, 2012) ? Using a new tool allowing proteins in a living cell to be manipulated in real time, researchers at Johns Hopkins have stumbled across the answer to a longstanding debate about where and how a certain protein is turned on in the cell. Reporting in the February 2012 issue of Nature Chemical Biology, scientists show that protein kinase A is also activated in the nucleus rather than inside the cell's body, a challenge to traditional beliefs.

"People have been wondering about nuclear PKA and [the answer] clicked when we saw our results," says Jin Zhang, Ph.D, associate professor of pharmacology at Johns Hopkins. For the most part, those in the field believe that PKA is activated in the cell's cytoplasm, but there is conflicting evidence suggesting it could also be present in the nucleus. Zhang says the answer to the debate clicked for her team when a cell biology technique they were fine-tuning gave them unusual results.

Zhang and her research team are looking for the best way to see what's happening in live cells in real time. Most recently, they developed a new tool to manipulate the intricate molecular signals within the cell, allowing the researchers to stimulate cellular activities so experiments rely on their timing rather than the cells'. The technique enables the scientists to chemically activate a chain of signals at a precise location and specific time, all of it culminating in the activation of PKA. This causes changes in the cell that lead to a variety of outcomes, from altering metabolism to causing a muscle contraction.

Given the wide range of cellular outcomes possible upon trigger of this chain of signals, Zhang and her team knew they must test their tool under many conditions to see the many different possibilities. They began by stimulating the chain at the edge of the cell. They measured how quickly the signaling chain responded, and engineers collaborating with Zhang came up with a mathematical equation to model the speed of the message going from the cell membrane into the nucleus.

Next, they tested their tool closer to the center of the cell, activating molecules at the edge of the nucleus. They found the response was much faster than anticipated; the mathematical equation did not fit. Thinking about this inconsistency led the team to conclude that the only way to explain their findings was if PKA was activated inside the nucleus, contrary to the traditional understanding of PKA being located and activated outside the nucleus.

According to Zhang, PKA has always been thought to be activated outside the nucleus. Upon activation, it travels into the nucleus to turn on the cell's response. Zhang's data showed the signal from PKA activated at the cell's edge is slow in reaching the inside of nucleus, so the only explanation for a fast response at the nucleus would be if another population of PKA was already there.

"We're collecting information that shows PKA at the nucleus is functional, it's not contamination and not background signal," says Zhang. "These are real functional enzymes that can be activated."

Zhang and her colleagues now aims to find out how PKA at the nucleus differs from traditional PKA. Without doubt, PKA plays a critical role in many cellular processes, says Zhang. This means that nuclear PKA could be a significant and, as yet, untapped source of information about cell function.

Authors on the paper include Vedangi Sample, Lisa M DiPilato, Qiang Ni and Jin Zhang of Johns Hopkins, and Jason H. Yang and Jeffrey J. Saucerman of University of Virginia.

This work was funded by U.S. National Institutes of Health grants R01 DK073368, DP1 OD006419, F31 DK074381, R01 HL094476, and GM08715, and the American Heart Association.

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Story Source:

The above story is reprinted from materials provided by Johns Hopkins Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Vedangi Sample, Lisa M DiPilato, Jason H Yang, Qiang Ni, Jeffrey J Saucerman, Jin Zhang. Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nature Chemical Biology, 2012; 8 (4): 375 DOI: 10.1038/nchembio.799

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

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Georgetown Security Law Brief: Court blocks Florida law barring ...

06/27/12: JURIST reports the US District Court for the Southern District of Florida issued a temporary injunction Monday blocking enforcement of a new Florida law that denies government contracts to companies that do business in Cuba or Syria. ?The law is currently facing a challenge from Odebrecht Construction Inc., a company that would be affected by the new legislation, arguing that the law is an unconstitutional intrusion in the Federal Government?s authority to regulate foreign affairs. ?In issuing the injunction, Judge K. Michael Moore noted that laws like this have not survived in the past.

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Writer and director Nora Ephron gravely ill with leukemia

(Nikki Kahn/The Washington Post/Getty Images) The writer and director Nora Ephron is gravely ill in her battle with leukemia, a source close to the family told ABC News.

Ephron, the writer of such iconic films as "Harry Met Sally," "Sleepless in Seattle,"? and "You've Got Mail," is 71 years old. Newspaper columnist Liz Smith told ABC that Ephron's funeral is already planned, and that Ephron is "deathly ill."

Writer Richard Cohen also confirmed to ABC News that Ephron's death is "imminent."

A source close to Ephron confirmed those reports.

Ephron is married to filmmaker Nicholas Pillegi, 79, and is the mother of two children from her previous marriage to journalist Carl Bernstein.

In recent years, Ephron earned acclaim for her novel about aging, "I Feel Bad About My Neck," as well as the play she coauthored with her daughter, "Love, Lost, and What I Wore."

She also wrote and directed the 2009 film "Julie and Julia," starring Meryl Streep and Amy Adams.

Ephron has won three Academy Awards for her work.?

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Wikipedia founder backs UK man wanted by US

1 day

Staff report , AP

The founder of Wikipedia urged British officials on Monday to block the extradition of a 24-year-old British student wanted in the United States over alleged copyright offenses.?

Wikipedia's Jimmy Wales expressed support for Richard O'Dwyer, who was arrested at his university dorm in 2010 by British officers accompanied by agents from the U.S. Immigration and Customs Enforcement. O'Dwyer's alleged crime was running a file-swapping website called TVShack.net, where users shared links to movies and television shows, many of them protected by copyright.

Wales said merely posting links is not a crime and urged citizens to stand up for their rights online.

"Richard O'Dwyer is the human face of the battle between the content industry and the interests of the general public," Wales said in an online petition posted on Change.org, adding that the student had always done his best to "play by the rules."

By midday Monday the petition to halt O'Dwyer's extradition had gained more than 20,400 signatures.

The Guardian newspaper has thrown its support behind O'Dwyer as well, saying in an editorial published Monday that his case was "unfair" and "absurd."?

In the United States, the Electronic Frontier Foundation?said it finds it "troubling" that the American government "is trying to haul a British citizen into?criminal court in the U.S. for running a website that probably doesn't?violate either U.S. law or U.K. law."

Mitch?Stoltz, staff attorney for the digital rights organization, told msnbc.com?that the government's actions in the case "send a dangerous message to other governments that websites?can be shut down and their operators threatened with prosecution in a?foreign country, no matter how tenuous the legal case. Surely the U.S.?government can come up with better ways to spend our tax dollars than?putting a British college student in jail for running what was, in?effect, a search engine."

Msnbc.com contributed to this report.

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